(SNRIs) Selective serotonin reuptake inhibitors (SSRIs) and selective serotonin-norepinephrine reuptake inhibitors (SNRIs)are suggested as first-line medications because of their favorable benefit-to-risk ratio. Patients should be aware that the anxiolytic effect of these antidepressants takes 2 to 4 weeks to appear (in some cases up to 6 weeks) (Leshem et al., 2021). Adverse effects may be more severe during the first two weeks. Initial jitteriness or a rise in anxiety symptoms may occur, reducing patient compliance with treatment. Lowering the antidepressant's beginning dose may help to alleviate these side effects. However, clinical evidence suggests that tolerance varies by patient and that an individual patient may suffer fewer side effects when switching from an SSRI to an SNRI. Because several SSRIs and SNRIs are cytochrome P450 enzyme inhibitors, they may interact with other psychopharmacological medicines and medical treatments (Leshem et al., 2021). Withdrawal symptoms may develop after quitting SSRI
Order this paper