Part 2 Following surgery, she was placed on morphine patient-controlled analgesia (PCA). She has been using 27 mg of morphine/24 hours with adequate pain control; however, she has developed redness and itching on her neck that is believed to be due to the morphine. Current Meds: Morphine PCA; metoprolol succinate ER 50 mg daily; rivaroxaban 20 mg daily; levothyroxine 150 mcg daily; polyethylene glycol 3350 17 g daily; lisinopril 2.5 mg daily; amiodarone 200 mg daily; sertraline 50 mg daily. She will be discharged to a skilled nursing facility for rehabilitation therapy. You would like to convert her to a combination preparation of hydrocodone / APAP. • What dosing regimen would you suggest? • Recommend a monitoring plan for this patient. • How would you assess pain response? • The patient is concerned about the redness and itching that he developed while on morphine. Would you document this as an allergic reaction? • What other interventions or education may be necessary at this time?

Part 2 After the surgery she was placed on a patient-controlled analgesia (PCA) pump because there were most likely concerns of swallowing issues which could lead to aspiration, especially in the elderly. “With PCA analgesia, avoid a basal infusion of opioid medication in opioid-naïve patients. The addition of acetaminophen or NSAIDs is associated with reduced opioid consumption and better pain control than using opioids alone” (Cadaval Gallardo et al., 2022). If there is a concern with swallowing then she should be administered Lovenox SQ or heparin IV, if in the hospital, until she is able to swallow. Even though she is having adequate pain control she has developed an adverse reaction to the morphine, and it should be discontinued but not considered a true allergy. Bronchospasm would be an indicator of a severe allergic reaction to the morphine. I would order Benadryl 50mg PO Q6 PRN to help with the redness and puritus. Based upon her current daily morphine dose of 27mg/day and using a conversion calculator with a 25% reduction yields a 51mg daily dose of hydrocodone. Hydrocodone 10/325mg PO Q6 PRN would be appropriate. This patient needs to be monitored closely for other adverse reactions and tolerance of switching to hydrocodone. She is already prescribed Miralax but a stool softener such as Colace 100mg PO BID should be incorporated into her plan. It would be important to educate her on increasing her PO fluids and ambulating frequently as tolerated. Early ambulation after surgery helps reduce the incidence of a post-operative ileus. A dietary plan to include sources of fiber would be beneficial without adding another medication to her list. Postoperative patients are at risk for developing pneumonia and they should be educated to perform deep breathing exercises at least every 30 minutes to promote good airflow into the lungs.

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