Thank you for your discussion post on pharmacokinetic and pharmacodynamics. I would like to add that during the initial treatment of the patient sublingual (SL) nitro 0.4mg can also be used for fast cardiac dilation and relief of chest pain. To combat hypotension intravenous fluid open wide if needed can also assist in the dizziness, nausea and vomiting associated with hypotension. As the patient was already in the hospital he would have been able to be assessed by professionals and received the recommended additional SL nitro within five minutes. According to the National Institute of Health [NIH]. 2020) SL nitro promotes peripheral pooling of blood, decreases venous return to the heart, and reduces left ventricular end-diastolic pressure (preload) NURS 6521 Week 1 Discussion: Pharmacokinetics and Pharmacodynamics essay. Nitroglycerin also produces arteriolar relaxation, thereby reducing peripheral vascular resistance and arterial pressure (afterload), and dilates large epicardial coronary arteries (2020). Morphine is one of the first-line medications in acute angina pectoris. However the addition of SL nitro may also be beneficial.
Reference:
National Institutes of Health. (2020). U.S. National Library of Medicine, DailyMed. Nitroglycerin. Drug label information. Retrieved from https://dailymed.nlm.nih.gov/dailymed/search.cfm?query=nitroglycerin
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