African-American men are reported to have more cases of gout arthritis compared to white men. From previous research studies, it has been found out that several differences exist in the genetic constituents of renal urate between African-American and white men. These differences account for the difference in number of gout Hyperuricemia cases. The higher prevalence of co-morbidities such as renal failure, hypertension and obesity also cause an increased burden of gout to the African-American men (Singh & Gaffo, 2020). Furthermore, delays in diagnosis and treatments as well as utilization of medications that are predisposing such as diuretics account for the higher number of gout patients among African-American men.
Having a history of diabetes mellitus and hypertension pose high possibilities of the patient developing gout. Increased uric acid also forms a higher risk of developing gouty arthritis. The patient’s obese condition and a recent history of hydrochlorothiazide intake also form a crucial role in gout pathogenesis. A sterile auto-inflammatory response to the crystals of monosodium-urate represents the gout flare. The auto-inflammatory response is characterized by erythema, heat, pain, swelling and loss of joint movement (Zhang et al., 2018). These are the exact signs and symptoms that the patient complains about. Moreover, the patient complains of having problems in the movement of the right first metatarsophalangeal which is the primary location where gout is known to attack. Although the patient is a white male who is less prevalent to gout attacks, his medical history suggest a higher chance of Hyperuricemia which is a primary cause of gouty arthritis.
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https://doi: 10.7150/thno.33908
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