Use this document to complete Part 1 of the Module 2 Assessment, Evidence-Based Project, Part 1: Identifying Research Methodologies.
| Full citation of selected article | Article #1 | Article #2 | Article #3 | Article #4 |
| Tolia, V. N., Murthy, K., Bennett, M. M., Greenberg, R. G., Benjamin, D. K., Smith, P. B., & Clark, R. H. (2018). Morphine vs. methadone treatment for infants with neonatal abstinence syndrome. The Journal of Pediatrics, 203, 185-189. https://doi.org/10.1016/j.jpeds.2018.07.061 | Sutter, M. B., Watson, H., Yonke, N., Weitzen, S., & Leeman, L. (2022). Morphine versus methadone for neonatal opioid withdrawal syndrome: a randomized controlled pilot study. BMC Pediatrics, 22(1), 1-7. https://doi.org/10.1186/s12887-022-03401-3 | Davis, J. M., Shenberger, J., Terrin, N., Breeze, J. L., Hudak, M., Wachman, E. M., … & Lester, B. (2018). Comparison of safety and efficacy of methadone vs. morphine for treatment of neonatal abstinence syndrome: a randomized clinical trial. JAMA Pediatrics, 172(8), 741-748. Doi:10.1001/jamapediatrics.2018.1307 | Gullickson, C., Kuhle, S., & Campbell‐Yeo, M. (2019). Comparison of outcomes between morphine and concomitant morphine and clonidine treatments for neonatal abstinence syndrome. Acta Paediatrica, 108(2), 271-274. https://doi.org/10.1111/apa.14491 | |
| Why you chose this article and/or how it relates to the clinical issue of interest (include a brief explanation of the ethics of research related to your clinical issue of interest) | This article was chosen because it is a primary peer-reviewed article. It relates to the clinical issue of interest (Treating Neonatal Abstinence Syndrome (NAS) in neonates) as it compares the efficacy of morphine and methadone as a form of treatment for NAS. The ethics of research related to the issue of interest include nonmaleficence and beneficence. | This article was chosen since it is a primary research article with one of the best research designs (randomized controlled trial). It is relevant as it reports the findings comparing the effectiveness of methadone and morphine in treating neonatal opioid withdrawal syndrome. It is important to determine which medication is more effective to reduce the length of hospitalization. The ethics of research related to the clinical issue include informed consent. | This article was chosen because it directly relates to the clinical topic of interest. It is also a primary peer-reviewed article; hence the results are valued. It relates to the clinical issue as it reports the findings of the use of methadone and morphine in neonatal abstinence syndrome. Among the ethics of research related to the issue of interest is informed consent. | This article was also chosen due to the fact that it is a peer-reviewed article that addresses the area of interest in relation to the treatment of NAS. The article is related to the area of interest since it focuses on the use of morphine in treating NAS. |
| Brief description of the aims of the research of each peer-reviewed article | The aim of the research was to compare the efficacy of morphine or methadone in reducing the length of stay among patients with neonatal abstinence syndrome. By identifying which medication is more effective infants will be treated more effectively, reducing the risk of long-term effects. | The aim of this study was to compare the length of treatment and hospital length of stay when using methadone and morphine to treat neonatal opioid withdrawal. This study identified that morphine is more effective in treating NAS and reduces the length of hospitalization. | The aim of this research was to determine the efficacy and safety of morphine and methadone in treating neonatal abstinence syndrome. | The aim of this study was to explore whether the addition of clonidine to morphine, as compared to morphine alone, is more effective in decreasing the length of treatment of patients with NAS. The study determined that adding clonidine
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