Alzheimer’s disease affects the whole brain, mainly the hippocampus and the posterior cortex, while frontotemporal dementia affects the temporal and frontal lobes of the brain (Kumar et al., 2022). Alzheimer’s disease in its early stages presents with memory loss and a decrease in cognitive abilities, while frontotemporal dementia in the early stages presents with personality and behavioral changes (Khan & De Jesus, 2022). Clinical findings that support a diagnosis of Alzheimer’s disease include a mini mental examination with a baseline score of 12 out of 30 and hippocampal atrophy seen on an MRI. The patient presenting complaints of memory loss, getting lost in the neighborhood, inability to dress, inability to balance his checkbook, and personality changes are signs and symptoms seen in Alzheimer’s disease. The amyloid hypothesis explains the development of Alzheimer’s disease and argues that the accumulation and deposition of fibrillary or oligomeric amyloid β peptide are the primary cause of Alzheimer’s disease (Kumar et al., 2022).
This patient’s likely stage of Alzheimer’s disease is mild Alzheimer’s disease. Patients diagnosed with mild Alzheimer’s disease present with memory loss, poor decision-making and compromised judgment, mood and personality changes, taking longer to accomplish daily activities, confusion on the location of familiar places, loss of sense of initiative, and challenges in handling money (Kumar et al., 2022). The patient’s wife reports that the patient has memory loss. He allowed a stranger into their house, which is a sign of compromised judgment and poor decision-making. The patient cannot find his way around the neighborhood despite living there for the past 35 years, which shows difficulty locating familiar places. The patient’s physical examination reveals that he is angry, which shows personality and mood changes. He cannot accomplish daily tasks such as dressing and might need the help of a caregiver. In addition, the patient is experiencing trouble handling money since he cannot balance his checkbook.
Khan, I., & De Jesus, O. (2022). Frontotemporal Lobe Dementia. StatPearls Publishing. https://www.ncbi.nlm.nih.gov/books/NBK559286/.
Kumar, A., Sidhu, J., Goyal, A., et al. (2022). Alzheimer Disease. StatPearls Publishing. https://www.ncbi.nlm.nih.gov/books/NBK499922/.
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