A 50yo African American woman presents to clinic feeling tired for the last 3 months. She also has trouble breathing when walking 2-3 blocks. She sleeps on 2 pillows at night to help with her breathing. PMH: HTN, arthritis. Physical exam: edema present in both feet. Medications: HCTZ 12.5mg daily, verapamil SA 120 mg daily, ibuprofen 200 mg BID for arthritis in knee. Vitals: height 5’2″, 63kg, BP 134/84, HR 78, EF 30% per echocardiogram. Her labs are normal including a creatinine of 1.1. She denies chest pain or palpitations. Her EKG reveals normal sinus rhythm with no evidence of ischemia or recent acute coronary syndrome Hypertension/Heart Failure Discussion Essays. How would you classify her heart failure? What changes (modifications, additions, deletions) to her medications do you recommend that will: Improve her symptoms? Impact long term outcomes? What monitoring parameters do you recommend? What non-pharmacologic recommendations do you have?

Our patient is endorsing symptoms of increased fatigue, shortness of breath with ordinary physical activity, edematous feet, orthopnea, and Stage 1 hypertension.  This symptomatology is consistent with a diagnosis of heart failure Stage C (SCHF) Class II with reduced ejection fraction (Yancy et al., 2018). Heart failure with reduced ejection fraction is also referred to as systolic heart failure (Saltzberg, 2016).  The endorsement of orthopnea is suggestive of congestion behind the ventricle, i.e. congestive heart failure.  These symptoms also suggest acute heart failure.  As this patient has a primary medical history of hypertension and arthritis, it can be assumed that a diagnosis of heart failure would be new for her.  A more thorough medical and social history is necessary to create a treatment plan.  It would be helpful to ask the patient if she coughs frequently, smokes, drinks alcohol, or has a family history of heart disease Hypertension/Heart Failure Discussion Essays.

Heart failure results from various functional and/or structural defects in the myocardium.  These defects result in a dysfunctional filling of the ventricles or ejection of blood (Inamdar & Inamdar, 2016).  These defects can result in decreased perfusion to the heart or an increased hemodynamic overload.  A major part of this underlying pathology is related to chronic inflammation, the dynamics of which may or may not be known.  Typical manifestations of left side heart failure include shortness of breath, crackles or diminished lung sounds, presence of a third heart sound or “gallop”, decreased urinary output, edema in the extremities, and dyspnea (Inamdar & Inamdar, 2016).

In this scenario, the patient is prescribed HCTZ and verapamil. Research suggests that calcium channel blockers, such as verapamil, may worsen heart failure in patients with decreased ejection fraction (Zaremski et al., 2018).  Hydrochlorothiazide (HCTZ), while known to be effective for hypertension, is not effective as monotherapy for a patient with symptomatic heart failure such as this patient (James et al., 2014).  As such, both verapamil and HCTZ should be discontinued.  The gold standard for heart failure is an angiotensin-converting enzyme inhibitor (ACE inhibitor), such as lisinopril or captopril. However, some evidence suggests that ACE inhibitor use in African Americans increases the risk of angioedema (Yancy et al., 2018).  However, this risk is only 0.5%, so an ACE inhibitor is still the recommended antihypertensive for SCHF. The patient should be started on 1 of 3 beta blockers proven to reduce morality: metoprolol, bisoprolol, or carvedilol (Saltzberg, 2016).   A loop diuretic, such as furosemide, is also recommended as the patient has edematous feet (Lloyd-Jones et al., 2017).  An additional option for the patient, as she is an African American, could be the combination of hydralazine and isosorbide dinitrate, which is recommended to reduce morality in this population (Saltzberg, 2016).  While ARNIs, such as sacubitril/valsartan were recently approved for patients with symptomatic HFrEF, evidence-based practice suggests these should be second line and reserved for patients unable to take ACE inhibitors or ARBs as ARNIs are expensive and have an increased risk of hypotension (Inamdar & Inamdar, 2016).  As a clinician, I would start this patient on lisinopril 5 mg once daily, furosemide 20 mg once daily, metoprolol 25 mg once daily, and bi-weekly potassium 20 mg.  The patient should be seen again in two weeks to evaluate effectiveness of therapy and plan to increase dosage as the patient is being started on low initial doses Hypertension/Heart Failure Discussion Essays.  The patient should be taught to weigh herself daily at the same time and record that weight.  The goal for the patient is a weight loss of up to 2 pounds per day (Yancy et al., 2018).  The patient should have regular monitoring of electrolytes and kidney function to ensure sodium and potassium are within normal limits and because ACE inhibitors can worsen renal function.  A serum creatinine should be included as ACE inhibitors can potentially increase this number.

While medications are helpful in managing heart failure, there are lifestyle modifications that should be included as well.  The patient should be instructed to decrease sodium intake to no more than 2 g/day, limit water intake to 2 liters per day, and follow the American Heart Association Step 2 Diet  (American Heart Association, 2017).  Light to moderate exercise should be incorporated.  Swimming, walking, and bike riding would be excellent choices.  Finally, the patient should be instructed not to smoke or drink alcohol and to consider utilizing acetaminophen for pain instead of ibuprofen, as NSAIDS can exacerbate heart fa

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