Evidence-based practice (EBP) is a systematic approach to patient care decision-making based on current, best available research evidence. The first step in EBP involves re-phrasing a clinical patient care issue in the form of a focused, searchable, and answerable question. PICO(T) is a template for creating a well-built clinical question for evidence-based inquiry. P - Patient/Population/Problem I - Intervention/Variable of Interest C - Comparison ("standard care" or "usual care") O - Outcome(s) T - Time In _____ (P), what is the effect of _____ (I), compared with _____ (C), on _____ (O) within _____ (T)?