Firstly, it is essential to apprehend the characteristics of the healthcare system at the local level; to ensure the effective implementation of EBP. Understanding the environment enlightens one on the expected outcome based on the available resources, organizational preparedness, and demographics (Kueny, Shever, Lehan, & Titler, 2015). During the third week, we identified the following implementation barriers to our project: lack of proper education of the CLABSI written policies, non-compliance with the regulations, shortage of nurses, and staff resistance to change. We noted that some of the nurses resisted change because they had little or no knowledge and training on EBP. Thus, it was essential for us to close the nurses’ personal barriers before implementing new EBPs. As a result, we identified a multi-disciplinary collaboration approach as a potential means of assessing the nurses, doctors, and healthcare specialists’ preparedness for the initiative