Introduction Human African Trypanosomiasis (HAT) is a disease caused by the transmission through the Trypansosoma brucei gambiense tsetse fly in West Africa which can be lethal often neglected disease. While the mangrove habitat is the typically prevalent area in West Africa there is minimal epidemiological data of the disease in the environmental living disease. There is significant likelihood HAT can be extremely prevalent in mangroves in Central Africa. As a means of obtaining an overall grasp of the transmission of HAT a geographical comprehension is necessary. A disease caused by two sub-species of trypanosome which is transmitted by tsetse flies Trypanosoma brucei gambiense (in West and Central Africa) and Trypanosoma brucei rhodesiense (in East and South Africa), with T. b. gambiense having been traced to cause more than 90% of diagnosed cases, (Bucheton, MacLeod, & Jamonneau, (2011, p. 438). Of the 36 countries endemic to the disease 20 are in close proximity to achieving no new cases while another eight have reported less than 100 per year, (Bucheton, MacLeod, & Jamonneau, (2011, p. 438). Data pertaining to the epidemiology of sleeping sickness in mangrove habitats is minimal while the biotope is one which is sustaining the most significant prevalence in West Africa, (Kagbadouno et al., 2012, p. e1949 ). Increasingly data indicates mangrove systems have supported adverse to active disclosure and treatment programs. As a result, expulsion, which is indicative of WHO’s goal is challenged in such arduous environments. In so doing, it is not been established if the barriers are a result of the behavior of the communities within the mangroves placing the inhabitants at an increased risk of exposure to the tsetse fly or is the population of the particular tsetse fly interaction the driving force behind the transmission of the disease. Hypothesis In the estuary of Rio Pongo, an area with an expansive area of sedimentation which has supported a large growth of mangrove trees. As a result various studies have taken place in an effort to better understand the epidemiology of HAT and implementation of focused control strategies. An improved process to identify population performance and environmental impact of the disease distribution within the Forecariah focus, produced the activities and daily tasks of the case studies. Research permitted researchers to determine the level of risk of the various tasks and identify the various elements and network with significant risk levels. As a result of the study outcomes have produced focused entomological and medical controls for HAT. According to Courtin et al., (2010, p. 881) mangroves, an inter-tropical ecosystem, is influenced by halophilic species of plants by which individuals earn an income. While in some areas the population is increasing to such an extent the mangrove habitat is shrinking significantly the demand for agriculture, wood and salt extraction is on the rise. Various studies have identified specific activities within the mangrove linked to the transmission of HAT specifically due to the primary vector of sleeping sickness in the country, Glossina palpalis gambiensis thrives upon. Considering mangroves in the area Guinea presents the highest prevalence of disease in West Africa, the number of studies pertaining to the transmission of the and spread of HAT have been minimal in this particular area of the country. Generally speaking, the fundamental knowledge of human behavior elements of risk necessitate a complete understanding of HAT epidemiology and implementation of focused control strategies. It has been assumed the number of T. b. gambiense transmission in the area has reduced can be related to a concomitant reduction in host-vector contacts linked to various factors such as climate changes, growth in population