Steps in Evidence-Based Practice in Nursing All that said, EBP is founded on six key steps as illustrated below. Step 1: Asking an Answerable Question Clinical nursing practice requires the nurse to find answers to treatment questions. This entails asking the appropriate PICO question for nursing. In this, practice may demand answers to questions or issues such as “most effective”, “quickest”, or “best” medication for a particular disease or condition. This practice requires you to get an evidence-based answer. As such, the first step towards getting this answer entails asking the appropriate clinical question. It is evident that clinical nursing questions could be complex, wide, and multi-leveled. For instance, a nurse may face a question like, “which asthma treatment is the most effective, fastest, and has the least side effects?” Answering such clinical questions requires a methodological approach. Markedly, the “PICO” framework is the scientifically approved approach for answering nursing questions. This framework stands for: P: Patient or Population I: Intervention or Indicator C: Comparison or Control O: Outcome T: Time