PICO Question Paper Introduction The writer will use the chosen topic of Central Line-associated bloodstream infections (CLABSI) for the capstone project change proposal and develop a framework using the PICOT question to writea PICOT question paper on CLABSI prevention through an evidence-based best practice solution, nursing intervention, staff, and patient education, CLABSI bundle approach implementation, reinforcement, and surveillance. The acronym PICOT stands for population, intervention, comparison, outcome, and time. In nursing research, PICOT is used to establish a research question that helps nurses to gather beneficial evidence. Nurses use Evidence-Based Practice (EBP) to provide safe, high-quality patient care and improve outcomes. The PICOT question leads to a research approach, leading to an unbiased and effective search (Ford & Melnyk, 2019). PICOT Question Population: Adult Patients admitted to the hospital in the ICU Stepdown unit. Intervention: Implement evidence-based practices such as the CLABSI bundle approach, use of chlorhexidine gluconate instead of povidone-iodine, staff, and patient education, enforcing proper hand hygiene, creating opportunities to practice and care for central lines and surveillance to observe adherence and obstacles to adopting new practices to prevent CLABSI, and interventions to remove obstacles hindering the adaptation of EB practice. Comparison: Does implementing the CLABSI bundle approach compare to the non-bundle approach, along with additional efforts and interventions like providing more training, education, skill practice, and removing any obstacles hindering the bundle approach, can prevent CLABSI; Outcome: Achieving the zero CLABSI goal for the unit. Time: In two months. PICOT Problem CLABSI is one of the most common hospital-acquired infections despite being preventable. CLABSIs are classified as hospital-acquired infections (HAIs). Despite significant progress in preventing HAI, much more work is still required; about one out of every 31 patients develop an infection linked to hospitalization. CLABSI remains to make up for 9.9% of all primary bloodstream infections (Monegro, 2023). About 250,000 CLABSIs occur yearly, with intravascular devices being the most common cause (Haddadin, 2022). Given the fact that CLABSI is preventable, the statistics are alarming; it still poses severe risks to patients and an enormous cost to any health organization. Preventing CLABSI can reduce mortality and morbidity through effective aseptic techniques, surveillance, and management strategies. Nursing Intervention This change project's primary nursing interventions for CLABSI prevention are the CLABSI bundle approach. In addition, Interventions supporting the suggested main intervention include education on preventative measures, execution of adequate hand hygiene among all staff, fostering of aseptic technique and adherence to it, creating opportunities for educational sessions for practice and care of central lines and surveillance to observe adherence and barriers to in utilizing new practices to prevent CLABSI, interventions to remove barriers impeding the embracement of EB practice, and use of chlorhexidine-gluconate instead of povidone-iodine, working with management, education department, and infection control to support and coordinate in implementing the nursing interventions. CLABSIs are preventable; thus, nurses must take the lead in preventing them. Clinical Problem and Outcome The goal of this change project is to minimize CLABSIs, meeting the gold standard goal of improving the quality of care for patients and maximizing positive outcomes. Helping meet the unit goal for zero CLABSI, have confident, skilled nurses comfortable practicing EB interventions for central line care with compliance to practicing all EB improvement interventions with obstacles removed hindering the EB practice. Nurses are at the forefront of ensuring patients acquire the best care feasible by employing all the nursing interventions described in this paper. Time frame Implementing interventions for the Capstone change project will occur over two months of proactive interventions and follow-ups. Conclusion CLABSI is a laboratory-confirmed bloodstream infection that develops unrelated to another infection and falls under the HAI (Haddadin, 2022). Using the PICOT question framework, a plan is developed for the CLABSI problem to implement EB interventions and how it can result in positive patient outcomes by reducing CLABSI during hospitalization. References Ford, L. G., & Melnyk, B. M. (2019). The Underappreciated and Misunderstood PICOT Question: A Critical Step in the EBP Process. Worldviews on Evidence-based Nursing, 16(6), 422-423. https://doi.org/10.1111/wvn.12408 Haddadin, Y. (2022, November 26). Central Line Associated Blood Stream Infections. Stat-Pearls - NCBI Bookshelf. https://www.ncbi.nlm.nih.gov/books/NBK430891/ Monegro, A. F. (2023, February 12). Hospital Acquired Infections. StatPearls - NCBI Bookshelf. https://www.ncbi.nlm.nih.gov/books/NBK441857/