The development of the COVID-19 pandemic altered infection control and prevention procedures in healthcare settings around the world. The purpose of this paper is to investigate the substantial impact of COVID-19 on these activities, the changes in procedures, and the long-term ramifications for healthcare facilities. COVID-19's Influence on Infection Control and Prevention Practices Protocols that are too strict: The pandemic prompted more stringent infection control measures, such as the use of Personal Protective Equipment (PPE) such as N95 masks, face shields, gowns, and gloves. To stop the spread of the virus, hand hygiene measures were enhanced, and environmental cleaning and disinfection were increased. Telehealth and Remote Care: Many healthcare providers use telehealth services to restrict in-person interactions and reduce the danger of viral transmission. This enabled remote diagnosis, monitoring, and care, lowering the risk of both patients and healthcare professionals. Procedures for Isolation and Triage: Healthcare facilities restructured their settings to create dedicated COVID-19 wards, distinct triage sections, and isolation units. This separation assisted in preventing cross-contamination between infected and non-infected patients. Visitor Restrictions: To reduce the risk of transmitting the virus into healthcare settings, hospitals implemented rigorous visitor policies that limited or prohibited visitors. Exceptions were frequently given for terminally ill patients or critical caretakers. Protocol and policy revisions PPE rules: To ensure enough supply and appropriate usage, revised rules on the use and conservation of PPE were established. To improve safety, healthcare personnel received updated training on donning and doffing procedures. Protocols for Testing and Screening: To quickly detect and isolate COVID-19 cases, robust testing and screening measures were implemented. The revised protocols included routine staff and patient testing. Enhanced Training and Education: To promote a higher level of care, healthcare personnel got extensive training and ongoing education on infection control methods, COVID-19 management, and the use of modern technologies. Long-Term Consequences and Future Practices Hybrid Care Model Adoption: The success of telehealth during the pandemic resulted in a wider adoption of hybrid care models, which combine in-person and remote healthcare services, altering the future of healthcare delivery. The necessity of planning and adaptability in reacting to unexpected infectious disease outbreaks was acknowledged by healthcare facilities. Protocol and infrastructure flexibility became a top goal. Collaboration and research have improved as a result of the pandemic, which has expedited collaboration among healthcare institutions, researchers, and public health organizations, enabling a collaborative effort to study, mitigate, and respond to infectious diseases. Conclusion COVID-19 had a significant and far-reaching impact on infection control and prevention strategies in healthcare settings. The pandemic produced a swift and dramatic shift in protocols, needing stringent controls, new recommendations, and a rethinking of patient care. The long-term consequences include a change toward more resilient and flexible healthcare systems, a greater emphasis on telehealth, and a greater emphasis on readiness and collaboration in the face of future infectious disease concerns. As a result, the healthcare industry is better able to manage and respond to changing infection control requirements, safeguarding the safety of both patients and healthcare personnel.