Summary: Escherichia coli (E. coli) O157:H7 was identified as pathogen in 1982 (Riley, et al., 1983) which causes hemolytic uremic syndrome (HUS) and was transmitted through undercooked ground beef paties (Bell, et al., 1994). The infection caused by E. coli tremendously up to 1994-2000 in U.S. (United State) and emerged as the pathogen threat. In this article Rangel et al. have been discussed the outbreaks of E. coli O157 in U.S. from 1982 to 2002 (Rangel et al., 2005). They highlighted the various factors which can be a reasoned for outbreaks of E. coli bacteria. The epidemiology data of E. coli obtained from Centers for Disease Control and Prevention (CDC). This study reviewed the data from 49 states which includes 350 outbreaks, 8598 cases, 1,493 hospitalization, 354 cases of hemolytic uremic syndrome and 40 deaths. After critically reviewing, the authors concluded that the transmission of E. coli is majorly through food (52%) and other contributing factors (Mead et al., 1999). This study allows the better understanding of the emerging pathogen E. coli O157 outbreaks and epidemiology, and helps in framing the policy and desired changes in life styles as prevention strategies by regulatory bodies.